Cryptotanshinone stat3
WebDec 31, 2008 · Cryptotanshinone binds to STAT3 monomer and inhibits the dimerization of STAT3. To visualize cryptotanshinone inhibition of STAT3 localization in intact cells, … WebOct 27, 2024 · Cryptotanshinone is a bioactive component present in the dried roots of Salviamiltiorrhiza Bunge (Danshen), and was reported, in the year 2009, as a STAT3 …
Cryptotanshinone stat3
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WebSTAT3 inhibitor (IC 50 = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti … WebCryptotanshinone. 本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。 ... Cryptotanshinone是一种STAT3抑制剂,在DU145细胞中能显着阻断STAT3 Tyr705磷酸化,但不能阻断STAT3 Ser727磷酸化,并显着抑制JAK2磷酸化,IC50为?5μM,而不影响上游 ...
WebMay 1, 2024 · Studies on the molecular mechanisms underlying the activities of cryptotanshinone have established that the JAK2/STAT3, PI3K/AKT, NF-κB, AMPK, and cell cycle pathways are involved in the inhibitory and pro-apoptotic effects of cryptotanshinone on different tumor cell lines, these molecular pathways interact in a coordinated manner … WebCTS is a cell-permeable diterpene quinone and its chemical name is 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro (1,2-b)furan-10,11-dione (CAS registry number: 35825-57-1), with a molecular formula of C 19 H 20 O 3, a molecular weight of …
WebAug 9, 2024 · Cryptotanshinone (CT) effectively inhibited glucose uptake and lactate production in ovarian cancer cells. CT exerted its anti‐tumor effect by targeting STAT3/SIRT3/HIF‐1α signaling pathway in vitro and in vivo. CT may be developed as a chemotherapeutic agent to treat ovarian cancer. Go to: 1. INTRODUCTION WebJul 20, 2024 · Unexpectedly, imatinib activates rather than inhibits the phosphorylation of STAT3 in K562 cells. We demonstrated that cryptotanshinone, as a dual inhibitor of p-STAT5 and p-STAT3, can effectively block IL-6-mediated STAT3 activation and reverse BCR-ABL kinase-independent drug resistance.
WebJul 20, 2024 · Cryptotanshinone depletes c-Myc in CML by repressing the phosphorylation of STAT5. Decreased viability of K562 cells correlated with p-STAT5 suppression. …
WebCostunolide, an active sesquiterpene lactone, is derived from several medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. Jin et al. showed that costunolide inhibited osteosarcoma growth and metastasis by suppressing STAT3 activity . Cryptotanshinone, an active quinoid diterpene, can be isolated from Salvia miltiorrhiza Bunge ... selling online sites free locallyWebjak-stat信号通路,能快速将受体接收到的膜外刺激信号传导入细胞内,进而调控下游相关基因的表达,实现受体-jak-stat-靶基因激活的高效信号传导反应.细胞活素或生长因子在细胞表面与其受体结合,致使jak2激酶c端的酪氨酸残基磷酸化,进而招募stat3,致其磷酸 ... selling online with wordpressWebOct 27, 2024 · Two STAT3 overactivated human TNBC cell lines (MDA-MB-231 and MDA-MB-468) were employed to test the activity of designed compounds with cryptotanshinone and BP-1-102 as the positive control by 3 ... selling online training coursesWebAug 26, 2024 · Hence, this study aims to explore whether TW-37 could be a valuable therapeutic option as monotherapy in human oral cancer, as well as combination therapy with cryptotanshinone, by targeting STAT3–Mcl-1 signaling. Methods Cell culture and chemical preparation selling online tips tricksWebApr 26, 2015 · Cryptotanshinone suppresses Stat3 phosphorylation in colorectal cancer cells. HCT116 and SW480 cells were seeded as 2 × 10 4 in 100-mm plates and after 24 h were treated with 0.1 % DMSO, 5, 10, 25, or 50 µmol/L CPT. After 24 h of treatment, extracts were analyzed by Western blotting analysis. a, c Total and phosphorylated Stat3. selling online without ebayWebanticancer therapy, that promotes the binding of signal transducer and activator of transcription 3 (STAT3) to Cryptotanshinone has been investigated. This binding tremendously reduces both the cellular production of STAT3, and the availability of the STAT3 dimers that drive production of various cellular oxygen and electron sources [11]. selling only in usa shopifyWebMay 21, 2024 · Cell Death & Disease - Retraction Note to: A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy selling only in us ebay