Cisplatin and electrolyte abnormalities

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August undefined, 2024

WebIn patients with gynecologic cancers, treated with cisplatin or cisplatin in combination with paclitaxel, a higher incidence of nephrotoxicity in the combination group was noted. 414 In addition, ... Electrolyte abnormalities that may either increase the toxicity of concomitant agents (hypokalemia in patients receiving digoxin) or may be ... WebSep 1, 2024 · Cisplatin for injectioncan cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Neurologic symptoms have …

Osmitrol (mannitol) dosing, indications, interactions, adverse …

WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude … WebA slight electrolyte imbalance may not cause noticeable changes. When problems occur, you may experience: Confusion and irritability. Diarrhea or constipation. Fatigue. Headaches. Irregular or fast heart rate (arrhythmia). Muscle cramps, muscle spasms or weakness. Nausea and vomiting. Numbness or tingling in limbs, fingers and toes. cs education pennant hills

Cisplatin: Package Insert - Drugs.com

Webelectrolyte imbalance (hyponatremia, hypochloremic alkalosis, hypokalemia, hypomagnesemia ... (with abnormalities of the fasting and 2-hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus has been reported. ... There is a risk of ototoxic effects if cisplatin and LASIX are given concomitantly. In addition, WebMay 18, 2024 · Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, … cs.edu book store

Cisplatin dosing, indications, interactions, adverse effects

Electrolyte Disorders Induced by Antineoplastic Drugs

WebJun 24, 2024 · Electrolyte abnormalities (hypokalemia, hypophosphatemia, and hypomagnesemia) Electrolyte abnormalities were defined as ≥ grade 1 hypokalemia, … WebFurosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, ... Abnormalities should be corrected or the drug temporarily withdrawn. Other medications may also influence serum electrolytes. ... There is a risk of ototoxic effects if cisplatin and ... cs education mount waverleyWebMay 24, 2006 · This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Cisplatin is a well-known nephrotoxic antineoplastic … csedw

"http://www.ejmanager.com/mnstemps/93/93-1446132625.pdf#:~:text=The%20most%20common%20electrolyte%20abnormality%20associated%20with%20cisplatin,the%20incidence%20of%20which%20varies%20significantly%20between%20studies. " - Cisplatin and electrolyte abnormalities

Cisplatin and electrolyte abnormalities

Web• Hypomagnesemia and Accompanying Electrolyte Abnormalities: Monitor during treatment and for at least 8 weeks following the completion. Replete electrolytes as necessary. (5.6) ... and Cisplatin . 5.6 Hypomagnesemia and Accompanying Electrolyte Abnormalities . 5.7 Increased Tumor Progression, Increased Mortality, or Lack ... WebNational Center for Biotechnology Information

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WebJun 8, 2024 · Cisplatin, the active ingredient in Cisplatin injection, is a yellow to orange crystalline powder with the molecular formula Cl 2 H 6 N 2 Pt and a molecular weight of 300.05. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. WebHypomagnesemia may cause nausea, vomiting, sleepiness, weakness, personality changes, muscle spasms, tremors, and loss of appetite. If severe, hypomagnesemia can cause seizures Seizure Disorders In seizure disorders, the brain's electrical activity is periodically disturbed, resulting in some degree of temporary brain dysfunction. Many …

WebJun 24, 2024 · Cisplatin-induced nephrotoxicity mainly manifests as kidney tubular injury leading to electrolyte disturbances manifested as hypomagnesemia, hypokalemia, and hypophosphatemia and/or increased serum creatinine (occurring more than 7 days after treatment initiation) and decreased glomerular filtration rate [ 8, 9 ]. WebJul 20, 2024 · Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, …

WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium wasting. … WebApr 12, 2024 · In cancer patients, electrolyte disorders are frequent due to tubular functional abnormalities related to chemotherapeutic drugs, the TLS and the impaired secretion of antidiuretic hormone ... As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced ...

WebBichet DG, Anderson RJ, Schrier RW (1993) Renal sodium excretion, edematous disorders, and diuretic use. In: Schrier RW (ed) Renal and electrolyte disorders, 4th edn. Little, Brown and Company, Boston, pp 89–161. Google Scholar Heyman SN, Spokes K, Egorin MJ, Epstein FH (1993) Glycine reduces early parenchymal uptake of cisplatin.

WebNov 1, 2024 · Vaughn E. Dobalian Abstract and Figures Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia,... csee8al03cWebAug 26, 2024 · Electrolyte disturbances can be caused by infections, medicines, trauma and surgery; poor nutritional intake and malabsorption can also contribute to deficiencies [3] . The exact incidence of electrolyte disturbances in the UK is difficult to define, as individual studies have tended to focus on the occurrence in discrete populations [4,5] . cs education penrithWebDec 15, 2024 · An electrolyte imbalance occurs when your body’s mineral levels are too high or too low. This can negatively affect vital body systems. Electrolytes must be evenly balanced for your body to... cs-education-technology-spread.pdfWebUse Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. ... Additive: etoposide w/ cisplatin & KCl(?), imipenem-cilastatin (may be used for shorter periods), meropenem (may be used for shorter periods) ... csed xjtu.edu.cnWebJun 26, 2024 · Nephrotoxicity-indicated by high serum creatinine, low estimated glomerular filtration rate (eGFR), and/or electrolyte abnormalities, appears in about one-third of … csedw wvWebMay 7, 2024 · For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the … csee8ar019WebOct 19, 2024 · Severe electrolyte abnormalities during cisplatin were associated with having 2–6-month CKD or hypertension (adjusted odds ratio (AdjOR) [95% CI]: 2.65 [1.04–6.74]). Having both AKI and severe electrolyte abnormalities was associated with 2–6-month hypertension (AdjOR [95% CI]: 3.64 [1.05–12.62]). Conclusions dyson tp04 high pitched noise